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    The fact that the effects of reversible MAO inhibitors are additive bears on the possible consequences, among obese European patients, of having taken both a fenfluramine and a multi-drug “compounded preparation” that frequently phentermine contained numerous MAO inhibitors, including amphetamine-like compounds [18] .
    The effects of unrecognized MAO inhibitors on pulmonary serotonin metabolism might also explain the tendency of fenfluramine-associated valvular lesions to affect the left side of the heart [1]—in contrast to the right-sided lesions found in patients with the carcinoid syndrome—as well as the reported association between fenfluramine use and primary pulmonary hypertension [18]: Most circulating serotonin is cleared adipex 37.5 tab qua phentermine 37.5 shelf life phentermine 37.5 reddit adipex diet pills drug in the lung, through metabolism by MAO [16] .
    In the carcinoid patient, pulmonary MAO is still active, so plasma serotonin concentrations in the right side of the heart are greater than those in the phentermine left side; however, as discussed above, in patients taking an MAO inhibitor the pulmonary clearance of serotonin is inhibited, TABLE 2 .
    EC50 values of MAO inhibitors for MAO-A and MAO-B in rat lung and brain homogenates MAO-A and MAO-B activities were assayed adipex dosage and administration adipex reviews before and after phentermine and prozac together and the concentration–inhibition curves obtained for their inhibition by known MAO-A and MAO-B inhibitors in lung and brain homogenates .
    The concentration producing 50% inhibition (IC50) was phentermine calculated graphically from semi-log plots (the concentration–inhibition curve) of inhibitor concentration against percent inhibition .
    Data are given as means ⫾ SEM phentermine of four determinations .

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